Research Group Jakob

Multiple Organ Failure

Main Areas of Work

  • Control of splanchnic blood flow
  • Mitochondrial dysfunction
  • Lactate metabolism
  • Organ dysfunction associated with sepsis

Brief description

We are investigating splanchnic perfusion in health and disease, and its role in the development of multiple organ failurewith a special focus on physiology and pathophysiology of liver blood flow and lactate kinetics. Further interests are theneuro-pathophysiology in critical illness, from cell culture to multicenter studies in patients, as well as translationalresearch in Intensive Care Medicine directed towards mitochondrial (dys-)function, especially induced by drugs but also insepsis and other diseases.

Associated staff

Sandra Nansoz

Prof. Dr. med. Jukka Takala
Prof. emeritus

Current projects

  • Liver and brain dysfunction in experimental sepsis
  • Effects of nursing procedures on hepatic, renal and cerebral oxygen transport
  • Effects of midazolam and propofol on primary hepatocytes and astrocytes

Important publication


Inselspital, Bern University Hospital and University of Bern

  • Department of Visceral Surgery and Medicine, Inselspital
  • Department of Neurosurgery, Inselspital
  • ARTORG, Center for Biomedical Engineering Research, University of Bern

National Collaborations

  • All Swiss University ICUs
  • ETH Zurich

International Collaborations

  • Perioperative, Intensive Care and Pain Medicine, Helsinki University Hospital
  • Department of Intensive Care, Rigshospitalet, Copenhagen